What do we know about Apo. E? I’m confused about Apo. E. And the more I read, the more I think I’m not alone. Of all the known genetic risk factors for late- onset Alzheimer disease, APOE genotype has by far the largest effect size — a single E4 allele increases your risk by ~3. X . If you believe, as I do, that human genetics is a valuable source of validation for therapeutic strategies, then it follows that Apo. E might be considered as one possible drug target for preventing Alzheimer disease.
People with the APOE e4 genetic variation have a greater number of sticky protein clumps, called beta-amyloid plaques, in the brain. Thus, a diet high in saturated. The trouble is, no one seems to know the mechanism by which the E4 allele increases Alzheimer risk. There is not even any agreement on whether E4 represents a gain of function or a loss of function, and therefore on whether one should strive to develop inhibitors or activators of Apo. ![]() E. Accordingly, people have taken approaches that are all over the map. Some think Apo. E is beneficial, and have sought to therapeutically upregulate APOE expression . Others view Apo. E as the enemy, and look to its knockdown or its inhibition with monoclonal antibodies as potential therapies . Still others believe that the answer is isoform- dependent, and that one should seek to downregulate the risk- increasing E4 isoform and/or upregulate the protective E2 isoform . And it’s not for lack of interest. One of the studies mentioned above . ![]() Paradoxically, all this literature makes my task harder, rather than easier. The literature is so crowded with different claims about APOE that it becomes incredibly difficult to tell what is real. For instance, in a quick Google Scholar search I spotted more than ten candidate gene studies proposing an association between APOE genotype and either the risk, age of onset, or phenotype of prion disease, even though in the largest prion disease GWAS to date . To believe everything in the literature, it seems, would be to believe this one protein is found in every subcellular compartment, interacts with every other protein, modulates every mouse phenotype, and is a risk factor for every neurological disease. I soon developed the following postulate: for every hypothesis that you can imagine about Apo. E, there exists a paper that claims it’s true. To try to sift through this morass, I figured I’d start with what I know best: human genetics. That’s not to say that human genetics papers about APOE are any more likely to be correct than papers about mouse models or cell biology or anything else, but rather, human genetics is a body of literature that I know how to read. I don’t always know a good mouse from a bad mouse or a representative image from a cherry- picked one, but I have at least a decent handle on the methods and statistical thresholds that pass for evidence in human genetics. So the question of this post, then: what does the human genetic data tell us about APOE? Be warned, even on this subject I’m far from an expert, so this post is very likely to contain mistakes and omissions. First, some general facts about APOE variation in humans. APOE consists of 3 exons located on chromosome 1. In terms of numbering, the coding sequence is 3. Two variants are common worldwide, C1. R (often called C1. R) and R1. 76. C (often R1. C), and another variant, R1. C (or R1. 45. C) has a frequency of 6% in Africans. ![]() ![]() And of course, as with any gene, there are loads of other less common variants — a total of 9. Ex. AC release. Other than the variants discussed above, plus one variant in the signal peptide (N1. K), none of these has an allele frequency greater than 1% in any large continental population. Note that, as is convention, the amino acid codes above are given in comparison to the reference genome, but in the case of C1. R, R is actually the ancestral allele, shared by chimpanzees and mice alike. ![]() ![]() This means that 1. C, which is the reference and the most common allele in all major world populations, actually arose in humans and swept to its current 7. Africa bottleneck. The R1. 58. C variant, which is found in cis with 1. C, must therefore have arisen later on that same new haplotype. People don’t often refer directly to these missense variants by their codon and resulting amino acid substitition as I’ve done above. Instead, one often hears a specific nomenclature for APOE variants, one which, as far as I can tell, arose by historical accident. Apo. E protein was studied using biochemical techniques years before DNA sequencing was in common use, and it was noticed early on that different versions of the protein had different isoelectric points and could be separated on 2. D gels. The term “E3” came to refer to the electrophoretic mobility of the protein encoded by the most common allele (now the reference). It turns out that most of the time, the underlying missense variants that gave rise to these differences were R1. C (E2) and C1. 12. R (E4), though there were exceptions: that common African R1. C variant mentioned above also has “E2” electrophoretic mobility, and there were other, rarer, variants as well, such as “E2 Fukuoka” (R2. Q) . As an additional historical curiosity, “E1” referred to Apo. E protein with two fewer positive charges than the reference E3 allele, and reported E1 alleles included K1. E . Nowadays, when people say E2 or E4, they’re no longer thinking of electrophoretic mobility, but instead are simply referring to R1. C and C1. 12. R respectively — and for the avoidance of confusion, I will refer directly to the missense variants in the rest of this post, with parenthetical reference to the “E” term in common use. Blood lipids and cardiovascular disease risk. Years before APOE was ever associated with Alzheimer disease, its protein product was known as a component of lipoprotein particles in the bloodstream. As far as I could find, the earliest reference to what we now call Apo. E may be the characterization of an “arginine- rich” (3. VLDL) particles in the blood of patients with a disorder called dysbetalipoproteinemia . Within a few years, the arginine- rich protein, christened Apo. ![]() ![]() E, was known to be present not just in VLDL, but also in chylomicrons and HDL . The APOE locus is reproducibly associated with LDL cholesterol levels in genome- wide association studies . None of those GWAS papers discussed the direction of effect nor whether the locus was also associated with coronary artery disease, but those issues were examined in detail in an enormous meta- analysis (~1. That study found that R1. C (E2) resulted in reduced LDL and reduced risk of coronary artery disease, while C1. R (E4) increased both. For LDL, R1. 58. C homozygotes (E2/E2) had 4. L lower LDL than C1. R homozygotes (E4/E4). In an allelic model, compared to the reference genome (E3), R1. C (E2) was associated with reduced risk of coronary artery disease (odds ratio = 0. C1. 12. R (E4) was associated with increased risk (OR = 1. At first glance, then, this all sounds straightforward: R1. C (E2) is good, and C1. R (E4) is bad. It’s not quite so simple, though. Although R1. 58. C (E2) on average is associated with reduced risk of cardiovascular disease, there seems to be a lot of variance in people’s outcomes, and the earliest studies of E2 actually examined its role in causing disease. It’s confusing, and I only wrapped my mind around it after finding one good thorough review . The R1. 58. C (E2) variant is described as being defective in receptor binding, thus causing Apo. Complete information for APOE gene (Protein Coding), Apolipoprotein E, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The. The lipoproteins page provides a detailed description of the structure and function of the lipoprotein particles found in the circulation as well as therapeutic means. E protein, which is found on chylomicrons, VLDL, IDL, HDL, to stay in the bloodstream and circulate longer. R1. 58. C (E2) is associated with increased levels of circulating Apo. E (associated with one or more of chylomicrons, VLDL, IDL, HDL) and decreased levels of circulating Apo. B (associated with LDL). So although LDL is apparently always decreased in these individuals, which is good, VLDL and other lipoprotein particles can be increased, sometimes pathologically so, such that a subset of R1. C homozygotes (E2/E2) actually suffer from a disorder called either dysbetalipoproteinemia or type 3 hyperlipoproteinemia. These people have very high total cholesterol, and develop xanthomas (visible deposits of cholesterol under their skin) and early- onset heart attacks. I couldn’t find any reference for what proportion of R1. C homozygotes (E2/E2) develop this condition, but it must be fairly small, since in the aggregate, even in a homozygous state, this variant appears to be associated with reduced risk of coronary artery disease . Individuals lacking a functional copy of APOE have low LDL but high levels of all other lipoprotein particle types, especially VLDL, which is increased by several- fold. This, at first, seemed incomprehensible to me: how could the absence of Apo. E cause the same disorder as homozygosity for R1. C (E2), which is associated with increased circulating Apo. ![]() E? Utermann speculates that any deficiency in Apo. E binding to its receptors, whether due to R1. C or due to total lack of Apo. E, results in upregulation of the LDL receptor (thus reducing LDL) but an inability to scavenge “remnant” lipoprotein particles such as VLDL and IDL (and thus an increase in levels of those particles). To date, several families with this recessive disease of APOE deficiency have been reported . There was also one individual with an “E1” missense allele in trans to a frameshift . Following the discovery of these families, Apoe knockout mice ? No one seems to know for sure. Certainly, the severe phenotypes of xanthomas and early onset atherosclerosis were only reported in double null individuals, and not in their heterozygote relatives. One proband did have an affected father, but he was deceased and his genotype was unknown, and 3 out of 6 of his children were affected . Some of the papers cited above do present VLDL, LDL, triglyceride and other blood lipid levels for one or two heterozygote relatives, but none of their numbers look to be glaringly outside the range in the general population, so it is not clear whether they are significantly shifted from the population distribution. One of the papers .
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![]() Bannerslider Forever. Aloe Vera Gel. Mit der Kraft von 1000 Sonnenstunden. Sport und Ernährung. Our organic Aloe Vera Juice is made from hand prepared organic inner leaf gel for better taste. Made from the highest organic grade, sustainably cultivated, and. The aloe vera miracle: A natural medicine for cancer, cholesterol, diabetes, inflammation, IBS, and other health conditions. Aloe vera pills can do wonders for your health but not if you don't take them correctly. Learn about aloe vera pill side effects before taking them! The metabolism miracle: The revolutionary diet that can help you stay slim forever. By Diane Kress Updated: 02:49 EDT, 6 January 2010. ![]() Aloe Vera Benefits, Research, Home Remedies, Side Effects. The beauty of Aloe vera can be matched with the beauty of its health benefits. Aloe vera benefits are not only limited to cosmetics. Botanical Name- Aloe Vera Chinensis, Aloe barbadensis Mill., Aloe indica, Aloe chinensis. More and more products are being created to help people consume aloe vera. One of the most popular is aloe vera juice. The benefits are many, and here are some of the. Aloe Vera juice is a yellow liquid which is extracted from the tubules of Aloe Vera plant. Aloe Vera plant is commonly found in African countries, Central Asia, and. Belly Fat Burner Water The 7 Day Detox Diet What Juices Detox Your Body Detox Tea Cranberry Lemon Alcohol Detox And Detoxification Diet Plan E numbers are essentially. Family Name- LILIACEAENames in different languages: Hindi name- Gheekuvar. English Name- Indian Aloe. Telugu Name- Kalabanda. Kannada name- Lolisara, Lolesara. Malayalam Name- Kumari, Kattar Vazha. ![]() Forever Young Aloe Vera DietaTamil Name- Kathaazhai. Bengali Name – Ghrita Kumari. Sanskrit Synonyms- Aloe vera is called as Kumari in Sanskrit. Kumari refers to a young girl. This name has two derivations. It is used in diseases of young girls, like pimples and menstrual problems. The plant is beautiful and looks young even after it grows old. Different varieties- At present A. Barbadensis, A. The author also noticed several other species of Aloe arebeing sold or cultivated in the name of Kumari in Kerala and Tamil Nadu. Distribution- cultivated throughout India. A. Vera chinensis- smaller Asi. ![]() TIC FROM, FLESHY, Lanceolate leaves 3. Aloe vera chemical constituents. Aloe- Emodin, aloctin A(Glycoprotein), Aloenin(bitter Glucoside), barbaloin, Chrysophanol Glycoside; Galactose, Mannose, Aldopentose, Aloesin, Aloeesone, b- sitosterol, Alocutin A & B etc.(Reference: Illustrated Dravyaguna VIjnana, Vol. II, by Dr JLN Shastry)Aloe vera medicinal properties. Rasa (taste) – Tikta (bitter)Guna (qualities) – Guru (heaviness), Snigdha (oily, unctuous), Picchila (sticky, slimy)Vipaka- Katu – Undergoes pungent taste conversion after digestion. Veerya – Sheeta – Cold potency. Effect on Tridosha – Balances all the three Doshas. Part Used- Leaves. Dosage- Fresh juice 1. Aqueous Extract 1. Leaf pulp – 1 – 3 grams. Aloe vera uses: Bhedani – Useful in constipation. Gulmahara – useful in abdominal tumors. Pleehahara – useful in spleen disorders, splenomegaly. Yakrut Vruddhihara – useful in hepatitis, hepatomegaly,Kapha Jwarahara – useful in fever. Granthihara – useful in small tumors, fibroids, lymphadenitis. Agnidagdha – useful in treating burn wounds. Visphotahara – relieves boils, blisters. Raktapittahara – Useful in bleeding disorders such as nasal bleeding, heavy periods, etc. Tvak Roga – useful in skin disorders, psoriasis. Chakshushya – improves vision, good for eyes, useful in eye disorders. Vishahara – Anti toxic. Vatahara – useful in treating disorders of Vata Dosha imbalance such as neuralgia, paralysis, constipation, bloating, etc. Balya – improves strength and immunity. Vrushya – aphrodisiac, improves vigor. Rasayana – anti aging, causes cell and tissue rejuvenation. Pittaja Kasahara – useful in cough and cold of Pitta origin. Shwasahara – useful in treatment of asthma and chronic respiratory disorders. Aloe vera for hemorrhoids: Because of its mild laxative action and wound healing properties, regular intake of mild doses of aloe vera in the form of capsule or juice, is very beneficial in hemorrhoids treatment. Aloe vera for heart –Aloe has blood thinning action. It is very useful against cholesterol. So, it is very useful in treating atherosclerosis (blood vessels clogged with clot and fat deposition). Aloe vera for women: Aloe vera improves ovulation chances, it induces menstruation, hence used in treating amenorrhea – absence of periods or decreased bleeding. It improves hair quality, prevents hair fall, cures dandruff, also useful in acne and blemishes. Aloe vera for constipation: To relieve constipation, its 1. It is administered in a dose of 3 – 6 grams, once a day. Aloe vera flowerbalances Vata and Pitta Dosha, Guru (heavy) and is useful in worm infestation, infected wounds Aloe vera side effects: Aloe vera induces purgation and hence it is not ideal to take it during diarrhea. Care should be exercised while using aloe in children and during lactation. It is best to avoid it during pregnancy. Aloe vera juice benefits- Aloe vera juice is good for stomach, in skin diseases, has anti- microbial properties. It also acts as a blood thinning agent and detoxifies blood. Daily dose is – 3. One teaspoon of this juice is added with two drops of ghee and 4 drops of honey and licked hourly to relieve the attack of breathlessness and wheezing. Aloe vera for eye redness and burning sensation: 2 grams of above purified (dry roasted) alum powder is mixed with 2. Aloe vera pulp and tied into two boli in clean pieces of cloth. These cloth packs are tied on eyes and kept as it overnight while sleeping. They are removed next morning. By this eyes become clear, vision improves, redness and burning sensation get subsided. Aloe vera for diabetes: Five phytosterols of aloe vera have been identified with anti- diabetic activity (research)Aloe vera has been clinically proven for anti diabetic property. A diabetic patient often suffers from blood vessel related disorders and is need of anti oxidant. Hence, aloe vera is a very useful herb in diabetes management. How to take aloe vera for diabetes? Along with your current anti diabetic medication, you can use aloe vera as a vegetable in your diet. Aloe vera capsule – 2 – 4 per day can be consumed depending on the blood sugar levels, in consultation with your doctor. Aloe vera juice (sugar- less, natural) can be taken in a dose of 1. The dose depends on the blood sugar level. Aloe vera for diverticulitis –Question: I understand that aloe vera juice helps patients with problem of diverticulitis. However, it relieves many of diverticulitis symptoms such as constipation (Aloe vera is a mild laxative), abdominal pain and Vomiting sensation. It helps to relieve early morning pain before the bladder and bowels are emptied. Research: In vitro Antibacterial activity. Evaluation of biological and toxicological properties How to use? Its pulp is used in small quantities as a vegetable. But over- dosage should be avoided. Its leaf is soaked in a cup of water over night. Next day morning, the water is consumed. Its extract in the form of capsule / tablet is administered under medical supervision. Its ready- to- use juices are available in the market. Because of its anti dandruff properties, its dry powder or pulp is used in making anti dandruff hair oil. Ayurvedic medicines containing Aloe as ingredient: Kumarayasav – used in abdominal distention, bloating, cough, cold, piles etc. Raja Pravartini Vati – used in treating amenorrhea and scanty bleeding. Mukta Panchamrit Ras – used in the treatment of Chronic fever, Pthisis, Emaciation, Cough etc. Karutha Gulika – used in treatment of headache. Aloe vera in preparing Bhasma –Aloe vera is used in incinerating copper metal into Tamra Bhasma (Copper calx). Similarly, it is used in preparing Pravala bhasma (coral), Shankha Bhasma (Conch Calx), Kapardika Bhasma (Cowries). Aloe vera for excess dry mouth: It helps to protect the sensitive tissue in the mouth and enhances the taste buds. Drink . Leave it for a few minutes and then rinse your mouth with water. ![]() ![]() How To Make A Weight Loss Green Smoothie. Green smoothies are an ideal fat burning food as they are nutrient- rich, loaded with fiber and low in fat. Water or plant milks like almond, coconut, hemp and cashew milk are low in fat and calories. Milk and yogurt add unnecessary fat and calories and have other possible negative health consequences that could undermine your health and weight loss goals. If you are concerned about calcium, find out how you make your green smoothies have more calcium than a glass of milk. Tip #2: Add a pinch of healthy fat. How much do you know about weight loss teas? Are they magic elixirs or the stuff of myth? Find out with our conclusive guide to weight loss teas. Nutrition facts and Information for Nuts, cashew nuts, raw. Looking for benefits of cashew nuts? Here are top 12 its advantages for health, skin &hair. Diana Fleming, Ph.D., nutritionist and co-author of the New York Times bestselling book The Full Plate Diet shares the six techniques she’s used to win the battle. Superb 100% FREE calorie counter apps. Over 35 million people have lost weight with FatSecret. Start your weight loss journey today and get access to the world's. We checked the labels for the healthiest peanut butter, almond butter, and other delicious spreads that will help you lose weight. Add 1/4 of an avocado, or a tablespoon of chia seeds or flaxseed, or some fresh young coconut to give your smoothie some heart healthy fats. Tip #3: Sweeten it with fruit. Don’t be afraid to use bananas, mangoes, grapes, and other sweet fruit in a weight loss green smoothie. If you absolutely must add a sweetener to your smoothie, try dates. Tip #4: Use a quality protein powder. Feel free to use a quality, plant- based protein powder in your green smoothies. I have found it very effective to use green smoothies as a meal replacement. Fresh fruits, vegetables and dark leafy greens are packed full of fiber, naturally water rich, and full of micronutrients that boost your metabolism. If you are looking to save money, buy frozen fruits or buy fresh in bulk and freeze for later use. Are you trying to lose weight healthfully? Then you might want to think about adding in coconut for weight loss. Here's what experts think. Want a tasty ingredient that’s decadent but also supports a trimmer tummy? Stock your kitchen with these 12 best healthy nut butters for weight loss. Pine nuts have been enjoyed since ancient times. Roman soldiers ate them and they’ve been mentioned by Greek authors as early as 300 BC. You can count the calories in thousands of foods with the Weight Loss Resources Calorie Counter and food diary tools. Exercise Calorie Counter. Avoid canned fruit as it is often soaked in syrup and nutritionally inferior to fresh fruit. Tip #7: Don’t rely only on green smoothies for weight loss. Green smoothies can certainly help you lose weight, but a long- term change in diet and lifestyle will provide long term results. Following a plan and putting a support system in place will help you reach your ideal weight faster, and with a greater chance of success. Cleansing with green smoothies is easy and can help you effectively lose weight (and bust through a plateau), increase energy, sleep better, improve digestion, decrease bloating, crave healthy foods, and clear away the mental fog. Check out Blend, my new 1. The Best Weight Loss Smoothie Foods. All fruits and vegetables are great for weight loss, but there are a few that stand out in the crowd. Foods that are low in calories and high in fiber are going make weight loss more effective. Some of the best ingredients to add to your weight loss green smoothies are grapefruit, pumpkin, kale, apples (with skin), blueberries, pomegranates, chia seeds, raspberries, pears (with skin), strawberries, bananas, oranges, broccoli, celery, cucumber, carrots and all leafy greens. Add either a tablespoon of chia seeds (soaked in water for 5 minutes), 1/4 avocado, or 1/4 cup of raw oats. Finish with a scoop of protein powder, if desired. Top 5 Weight Loss Green Smoothies: Apple- Coconut Weight Loss Booster. Cocoa- Berry Chia Smoothie Coconut- Lime Green Smoothie Beat Chocolate Cravings With This Green Smoothie! Strawberry Basil Green Smoothie Be sure to read my in- depth, 3- step guide to losing weight with green smoothies and whole foods. What You Need to Know About Cashew Milk. The good: They’re a great option both for vegans and the ~6. Another bonus: They’re cholesterol and saturated fat free. The not- so- good: Anyone with tree nut allergies, beware. Nut milks also have very little protein—far less than cow’s milk. Some varieties also have a lot of added sugars, salt, and thickeners, too. How it’s made: Nuts are first shelled, often lightly toasted, soaked in filtered water, ground into a paste, and then blended with water. The “milk” is the liquid that is then strained from the nut solids, or pulp. Some manufacturers then add thickeners or gums, sugar, salt, and flavors. Most of the calories, fat, fiber, protein, vitamins, and minerals are left in the pulp. About cashew milk: There are ups and downs. It’s a rough comparison when you look at whole cashews versus cashew milk, but here’s the rundown: On the upside, a cup of unsweetened cashew milk has just 2. On the downside, when the pulp is strained from the milk, you lose almost all of the fiber, protein, vitamins, and minerals from the whole nut. A cup of the milk contains 0g fiber and only < 1g protein, and if you choose the original variety, you’ll also tack on 7g added sugar and 1. Compared to cow’s milk (per 8 ounces): Original Silk Cashew Milk. Unsweetened Silk Cashew Milk. Skim Milk. 2% Milk. DV calcium (all added in processing)4. DV calcium (all added in processing)3. DV calcium. 30% DV calcium. Other cashew milk bonuses: Unlike cow’s milk, cashew milk has no naturally occurring sugars, so it won’t send your blood sugar into a spike. A cup contains 5. Vitamin E needs (that’s even more than almond milk), which is good for your skin and helps protect against sun damage. Most of us get plenty of protein in a day, so the fact that the milk only has about 1 gram per cup isn’t something most of us should necessarily worry about. If your meal does need a protein boost, you’ve got plenty of room to add since 1 cup of the unsweetened has only 2. How does it taste? We loved it! Creamy and rich with a nuttiness that was a bit more subtle than almond milk ! Choose the unsweetened variety if you’re looking for a no- sugar- added option. Pricing? I went to my local Publix for a little price comparison, and here’s what I found: Half gallon cashew milk: $2. Just be sure to read labels and know what you’re putting your money into . If not, choose unsweetened. And be sure to include some protein on the plate to help round out the meal. ![]() ![]() ![]() Here's how to assess your horse's risk for gastroint. The subject of equine diet and nutrition is a very slippery slope, as anyone who has tried to make sense out of it can testify. This page is crammed full of. 16 Hour Hoof Rehabilitation Series. This video is designed to teach equine professionals and horse owners new ways to recognize and treat hoof pathology. Edit Article wiki How to Manage a Laminitis Prone Horse. Laminitis (commonly called founder in more serious cases) is a painful and distressing condition of the hoof. EQUINE LAMINITIS. Abstracted from the scrutineered veterinary journal In Practice July 1990 pp156-161. How to care for the basic health needs of horses. Diseases and Conditions. Horse-health-problem risk factors, prevention, diagnosis, and treatment. Over generations, a plant-based diet results in genetic mutations which boost people's production of arachidonic acid. This fatty acid increases the risk of disease. Bare Foot Horse. Flares. Most of the problems we see in the hooves of domestic. Other than laminitis, in which inflammation of. What is a. flare? A flare is separation of the hoof wall, away from. Sometimes the wall curves outwards at the bottom like the bell of a trumpet. You can feel the slightest flare with your hand, and you can generally see a flare by placing your eye or camera at ground level, and moving around the foot to see all parts of the wall. A flare due to laminitis or long- term mechanical. The angle of the wall changes abruptly, high up - - sometimes so close to the coronet that you can't see where it changes. Flare tells us that white line stretching. Flare and stretched white line are the. When you look at the sole. To say. it the other way around, you will find a flare where the white line is. When the white line has stretched apart, the wall and bone cannot re- attach to each other. A new connection must grow down. ![]() Most flares occur at the bottom of the wall, where. The white. line at the bulge is stretched because the unusual mechanical forces in. A founder is a flare so severe that the. P2- P3 joint) downwards at the toe. The hoof wall is fingernail. Flaring feels something like having your fingernail pulled. Laminitis (inflammation of the white line) is so painful the horse. A horse living. in . The flared wall chips, cracks, and. Flares in domestic horses. Flares are common in domestic horses. Mechanical. flares happen when a hoof is overgrown or imbalanced. If the horse lives. In addition, we see laminitic flares in these same wet areas, because. Excellent recommendations for care of the insulin- resistant. Hooves that live on wet. Here in the Northeast USA, it is. We have to trim every 2 to 3 weeks - - 1. Just a few days' overgrowth allows. The combination of . This is a mechanical flare - -. One side. has broken away at the quarter - - it's starting to self- trim. The other quarter is flaring a lot and will break away soon. The excess wall needs to be trimmed to the edge of the sole, and the bars to the level of the sole. Other than being overgrown, this is a nice, healthy foot. A typical domestic hoof with a . Flare at the quarters (white arrow). Small groove where the white line is separated (black arrow). The flare will disappear with a consistently applied mustang roll. The horse foundered a year before. The. toe appears straight, but there is a bend in the toe angle just below. I put a line following the direction of growth at. The heel has also gotten very long, typical in a chronic founder. A mechanical flare due to overgrowth. Toe forced forward by the. Arrow points to the change in wall angle. This is where I believe. A draft horse, living on wet pasture without trimming, has trimmed. Looks awful. but it works for the horse. The hoof wall is thick, but soft, and breaks away easily. Before riding, we will shorten the wall to the level of the sole, and smooth the jagged edge on the wall with a good mustang roll. Here is a foot where the toe has flared so that it's not a straight. I have marked where the toe should be, following the upper part of. Where the toe sticks out in front of the line, the wall. Flares in domestic horses. Flares are common in domestic horses. Mechanical flares happen when a hoof is overgrown or imbalanced. If the horse lives in a wet climate. Natural hoof care is the practice of keeping horses so that their hooves are worn down naturally and so do not suffer overgrowth, splitting and other disorders. I explained that the grass laminitis weakens the white line so that the toe flares more easily. Changing the diet (see www. Also. the edge has been rounded. Here is a foot with no flare, showing the perfectly straight toe. The white line separates, the coffin bone loses some suspension. Although the horse. The idea is to remove flared parts of the wall from. When the white line tightens up (is no longer a groove or no longer dirty) which may take several months, then you can go back to a normal mustang roll, ending it at the water line. To rehabilitate a flare, mustang roll to the edge of the sole. Several months of the White Line Strategy trim, shown on my Do Trim page, will allow more toe length and sole thickness to grow. The front coffin bone has a shallower concavity so it can take a hard landing without cracking. On a draft horse, given how wide the foot is, a normal sole looks nearly flat. A truly flat. (foundered) sole is scary if you ever see one - - the foot looks like a block. You will know the difference! Hind feet are more concave because the. The hind feet are the horse's . In working with several hundred horses. USA, I have not yet seen a true case of white line disease. In true white line disease, fungus and/or bacteria. My understanding is that a hoof with. The best. treatment I have heard about is to soak several times with Clean. Barefoot Horse - Transition from Shod to Barefoot. How long does barefoot transition take? Some horses step out of their shoes and don't seem to notice,Some horses blink with surprise and run off bucking,Some have a week or two of footiness, then go from strength to strength. But for many, especially those with hidden metabolic issues, the process can take a. Start your transition journey with an honest assessment of where your horse and their hooves. Length of time to transition depends on a mix of factors including: Health of horse. How long shod. How shod. Condition of hooves/shape. Facilities/environment. Excercise/movement. The hardest part of transition though is often the changes that need to be made by the main carer. If you don't know quite what the metabolic issue is, beware of leaping on fashionable bandwagons. Yes really strict, no TGI Friday moments, they can really mess with your horse. Do not believe the big writing on bags of horse food. Take. video too if you can. Keep a diary of feed, behaviour, hoof health, gut health, work load, grass, weather. Learn to take a step back and reflect before panicking (very useful skill in true emergency situations). Chat up an independent (of feed companies) equine nutritionist. Research the equine digestive system (it is truly fascinating - yes really). Enlist a barefoot friend for support. Prepare open, non threatening questions for any professionals whose support or opinion you may need and learn to. Try to avoid just managing symptoms and instead tackle the cause whenever possible. Read this blog and http: //danceswithgrace. Sell the horse and get a motorbike (ONLY JOKING!).*Good books, all available from Amazon include: The Natural Horse: Lessons From the Wild (1. Horse Owners Guide to Natural Hoof Care (1. Founder: Prevention & Cure the Natural Way (2. Guide to Booting Horses for Hoof Care Professionals (2. Paddock Paradise: A Guide for Natural Horse Boarding (2. Ouchiness - several hours post shoe removal. So you have done your preparation - improved your horse's diet for at least several weeks before shoe removal. Excitement is mixed with a bit of trepidation; but you know it will be ok because all the horses you hear about. Only it's not. Your horse was ok immediately post shoe removal but within hours they are looking uncomfortable, maybe just on one. So why? Well - you need on the spot experienced barefoot help to identify the actual problem but here are some starters for ten. And don't forget, if in doubt always call your vet.
Turmeric Works Better than Drugs for Rheumatoid Arthritis. By Dr. Mercola. If you're looking for a way to help fight rheumatoid arthritis (RA) without drugs, then you need look no further than the spice shelf at your local market. New research published in the spring of 2. The clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with an NSAID drug (Voltaren) in patients with active RA.. It is a much more devastating illness than previously appreciated. This is NOT the same condition as the far more common and generally less serious osteoarthritis or degenerative joint disease. Although interestingly most of the same treatments discussed below will also work for osteoarthritis. Most patients with rheumatoid arthritis have a progressive disability, and the natural course of the condition is quite remarkable in that less than 1 percent of people with the disease have a spontaneous remission. Some disability occurs in 5. The annual cost of this disease in the U. ![]() S. Most authorities believe that remissions rarely occur. Some experts feel that the term . This devastating prognosis is what makes this novel form of treatment so exciting, as it has a far higher likelihood of succeeding than the conventional approach. Over the years I have treated over 3,0. SLE, scleroderma, polymyositis and dermatomyositis. Approximately 1. 5 percent of these patients were lost to follow- up for whatever reason and have not continued with treatment. The remaining patients appear to have a 6. This level of improvement is quite a stark in contrast to the typical numbers quoted above which are experienced with conventional approaches, and certainly provide a strong motivation to try the protocol I discuss below. Changes to My Rheumatoid Arthritis Video and Protocol. Many of you may know that I treated many RA patients based on a protocol developed by a maverick but well respected rheumatologist, Dr. Thomas Brown. He died in 1. I started using his approach. I first became aware of Doctor Brown's protocol, which focused on the elimination of mycoplasma, in 1. This chart graphically details the %DV that a serving of Turmeric provides for each of the nutrients of which it is a good, very good, or excellent source according. Rheumatoid arthritis management can be achieved through an anti-inflammatory diet and Mediterranean diet in order to reduce inflammation. Nutrition plays a vital role. I saw him on ABC's 2. This was shortly after the introduction of the first edition of his book, The Road Back. Unfortunately, Dr. Brown died from prostate cancer shortly after the 2. I never had a chance to meet him. ![]() Check out this guide to anti-inflammatory herbs, vitamins, and supplements for rheumatoid arthritis. Find out what works and what doesn't. If you have rheumatoid arthritis (RA), you know how painful it can be. The condition is characterized by swollen and painful joints. It can strike anyone at any age. For those that think arthritis is just a disease of old age or that it only affects those that are unhealthy, think again. Arthritis is actually a complex group of. ![]() I eventually wound up treating a few thousand RA patients and had quite a following as most got really great results. As I learned more about natural medicine I integrated more of that wisdom into Dr. Brown's original protocol and consolidated that into an article I wrote in 1. Many of the key points are summarized below. I further revised that paper with the video above but there have been further modifications to the RA protocol since I recorded this video. One of the primary ones is the strong recommendation to use low dose naltrexone as an adjunct to help wean off the nearly universal experience of toxic drugs that most RA patients are put on. Astaxanthin is also a powerful anti- inflammatory antioxidant that could have very powerful benefits in controlling the joint pain. Additionally, I would also strongly encourage working up to 4- 6 ounces a day of fermented veggies, which will supply about ten trillion beneficial bacteria, which is about 1. Ideally one should consume them regularly if not daily. The best way to learn how to prepare them properly is to get the GAPS book or listen to my interview with Caroline Barringer. Lastly of course, as the featured study suggests, one can also consider the use of curcumin as discussed below. Curcumin Works Better Than Drugs. The study revealed that a highly bioavailable form of curcumin was more effective in alleviating RA symptoms, including tenderness and swelling of joints, than the drug. Not only that, those who were taking the curcumin only, actually experienced the most improvement across the board. Along with relieving the most symptoms, the curcumin group had another benefit – lack of any observed adverse effects. No one in the curcumin group withdrew from the study due to side effects, but 1. NSAID group did so. Researchers noted: i. More importantly, curcumin treatment was found to be safe and did not relate with any adverse events. Our study provides the first evidence for the safety and superiority of curcumin treatment in patients with active RA. Curcumin is most known for its potent anti- inflammatory properties. It has been shown to influence more than 7. COX2) and 5- lipooxygenase (5- LOX), as well as other enzymes that have been implicated in inflammation. Tips for Increasing Your Absorption of Curcumin. If you want to give curcumin a try for RA, it is widely available in supplement form, but relatively high doses are required to achieve its therapeutic effects, and curcumin is generally not absorbed that well. Typical therapeutic doses are up to three grams of bioavailable curcumin extract, three to four times daily, and this is difficult to achieve using standard curcumin powders. One alternative is to make a microemulsion by combining a tablespoon of curcumin powder with 1- 2 egg yolks and a teaspoon or two of melted coconut oil. Then use a hand blender on high speed to emulsify the powder. Another strategy you can use to increase absorption is to put one tablespoon of the curcumin powder into a quart of boiling water. It must be boiling when you add the powder, as it will not work as well if you put it in room temperature water and heat the water and curcumin together. After boiling it for 1. The curcumin will gradually fall out of the solution over time and in about six hours it will be a 6% solution, so it is best to drink the water within four hours. It does have a woody taste, but this is done more for therapeutic benefits than flavor. One caution: curcumin is a very potent yellow pigment and can permanently discolor surfaces if you aren't careful. You can also use turmeric liberally in your cooking; it has an earthy, peppery flavor. Choose a pure turmeric powder, rather than a curry powder, as at least one study has found that curry powders tend to contain very little curcumin. We are currently sponsoring some clinical trials with a concentrated highly absorbable form of curcumin that we hope to have available in the next year or so. Why You Need to be Careful With NSAIDs. One of the primary problems with RA is controlling pain. Effective pain relief is obviously very important, and if this is not achieved, you can go into a depressive cycle that can worsen your immune system function and cause the RA to flare up. But the conventional treatment typically includes using very dangerous drugs like prednisone, methotrexate, and drugs that interfere with tumor necrosis factor, like Enbrel. Many also depend on non- steroidal anti- inflammatories (NSAIDs) like ibuprofen (Motrin) to manage this pain, but the regular, chronic use of these types of medications is associated with close to 1. Cardiovascular problems Gastrointestinal harm Kidney and/or liver damage Hearing Loss Miscarriage If you are taking an NSAID and you have a history of heart disease, you are at a 1. CHF). In fact, regular use of NSAIDs is the second major cause for ulcers. In addition, there are some general principles that seem to hold true for virtually everyone and these include: Eliminating sugar, especially fructose, and most grains. For most people with RA, you'll want to be very careful to limit fructose to just 1. Sugar has multiple significant negative influences on your biochemistry. First and foremost, it increases your insulin levels, which is the root cause of nearly all chronic disease. It can also impair your gut bacteria. In my experience if you are unable to decrease your sugar intake, you are far less likely to improve. One of the first steps you can take is to phase out all soda, and replace it with pure, clean water. Krill oil seems to be particularly helpful here, as it appears to be a more effective anti- inflammatory preparation. It is particularly effective if taken concurrently with 4 mg of astaxanthin, which is a potent antioxidant carotenoid derived from algae As astaxanthin offers potent protection against cataracts and age- related macular degeneration, 4 to perhaps 2. Incorporating regular exercise into your daily schedule, as described in detail below Early Emotional Traumas are Pervasive in Those with RA With the vast majority of the patients I treated, some type of emotional trauma occurred early in their life, before the age their conscious mind was formed, which is typically around the age of 5 or 6. However, a trauma can occur at any age, and has a profoundly negative impact. If that specific emotional insult is not addressed with an effective treatment modality then the underlying emotional trigger will continue to fester, allowing the destructive process to proceed, which can predispose you to severe autoimmune diseases like RA later in life. In some cases, RA appears to be triggered by an infection, and it is my experience that this infection is usually acquired when you have a stressful event that causes a disruption in your bioelectrical circuits, which then impairs your immune system. This early emotional trauma predisposes you to developing the initial infection, and also contributes to your relative inability to effectively defeat the infection. Therefore, it's very important to have an effective tool to address these underlying emotional traumas. In my practice, the most common form of treatment used is called the Emotional Freedom Technique (EFT). Although EFT is something that you can learn to do yourself in the comfort of your own home, it is important to consult a well- trained professional to obtain the skills necessary to promote proper healing using this amazing tool. Vitamin D Deficiency Rampant in Those with RAThe early part of the 2. D, particularly in the treatment of autoimmune diseases like RA. Home Remedies for Arthritis Pain: Symptoms, Treatment, Causes, Diet. In older people, who are most susceptible to this condition, arthritis is the leading cause of restriction of movement or immobility. Arthritis is a condition that we are all quite familiar with and even if you haven. Arthritis is a degenerative condition that affects the joints causing severe pain and greatly reducing mobility. In severe cases and if neglected the effects can be debilitating. Arthritis is typically associated with old age and although most prevalent among the aged it can affect almost anyone, but this it is uncommon among young adults and children. Arthritis may not be a life threatening condition but it is a dreaded condition because of the extent to which it affects your life. Simple tasks and routines that we normally take for granted can become quite a challenge. For example, arthritis in the hands, wrists or fingers can make working at the computer near impossible. While it can be quite debilitating it is not unmanageable. Arthritis can be managed and controlled to minimize its impact on your life. But to effectively control and treat the condition you need to be well informed and understand the condition. It is derived from two Greek words: athron, meaning joints; and itis, meaning inflammation. It is, generally, a chronic disease process. Arthritis occurs in various forms, the most frequent being osteoarthritis and rheumatoid arthritis. Osteoarthritis is a degenerative joint disease which usually occurs in the older age- group. Rheumatoid arthritis is a serious disease which affects not only the joints of the fingers, wrists, hips, knees, and feet, but also the muscles, tendons and other tissues of the body. There are a lot of different kinds of arthritis, categorized according to the extent of wear and tear in the joints and the cartilaginous tissues. Sometimes, the inflammation could be caused due to excessive wear and tear of the joints. However, the inflammation could also be caused due to autoimmune disorders. Such disorders, in which the immune system attacks the joints, are one of the leading causes of arthritis and rheumatism. All of our bodily movements and our mobility or flexibility is dependent on the proper functioning of the joints. Swelling or inflammation of the joints, which is typical of most types of arthritis, can however cause the joints to get severely damaged over time. Some forms of arthritis can even cause problems in organs like the eyes or skin. Some types of arthritis may also develop as a result of your immune system turning on your own body. The immune system which normally protects against infections may begin attacking your own body. Although arthritis is by and large associated with old age or aging, the condition can also affect children. Juvenile rheumatoid arthritis is fortunately a very rare condition. At times arthritis may develop as a result of an infections spreading from one part of the body to the joint, and this is termed as infectious arthritis. The main focus of arthritis treatment, whether with conventional treatment or with natural arthritis remedies is towards preventing further deterioration of the joints and to increase and preserve mobility, while restricting arthritis pain. Arthritis pain relief and management is best achieved through a combination of medical treatments and natural remedies or self care that could include specialized arthritis diet plans, lifestyle routines, and physiotherapy that may include specific exercises like yoga or pilates. Women suffering from arthritis should give serious thought to a decision to get pregnant because of the risk of complications. Symptoms of Arthritis. Pain and Stiffness in the Joints, Anaemia, Colitis. The main symptoms of osteoarthritis are pain and stiffness in the joints. The pain usually increases after exercise. Rheumatoid arthritis is often called the 'cooked food disease'. Ultimately the whole body is affected. Symptoms include anemia, colitis, constipation, deformed hands and feet. These symptoms are generally most severe when you wake up each morning. You may also notice the appearance of blotchy rashes on the arms and legs. This is accompanied by swelling and eventually leads to deformity. The condition may be caused by hormonal imbalance, physical and emotional stress, infection, severe fright, shock, and injury. Heredity. Hereditary factors may also be responsible for the onset of this disease. Arthritis Causes. There are various types of arthritis and accordingly a number of possible causes. Arthritis generally does involve a breakdown and deterioration of cartilage however, which is essential for protection of the joints to enable smooth movement. With the destruction of or loss of cartilage there is some amount of friction as the bones make contact causing severe pain and swelling. The causes of arthritis in the back, neck, hips, knees, elbows, wrists, and ankles or other joints could be attributed to various factors such as autoimmune diseases, bone damage, general wear and tear or aging, or because of infection. If caused by some other condition the inflammation or other symptoms of arthritis should resolve once the infection has been treated or the injury healed. At times however the condition will not resolve even after the elimination of the cause as you may have developed chronic arthritis. Arthritis like osteoarthritis is also age related and it will not go away completely. Some factors that put you at risk of developing arthritis however include being overweight. Obesity may cause arthritis to develop a lot more easily because of the high amount of stress and pressure on the joints. Performing certain repetitive movements like repeatedly hammering at a nail or batting could put stress on the concerned joint, which is why construction workers or baseball players for example are at risk. A lack of physical activity also contributes to deterioration and muscle or tissue loss and may contribute to arthritis. An unhealthy diet that is excessively high in fat or previous injuries to a joint may also contribute to the eventual development of arthritis. Remedies for Arthritis. Arthritis Treatment Using Potato Juice. The raw potato juice therapy is considered one of the most successful biological treatments for rheumatic and arthritic conditions. It has been used in folk medicine for centuries. The traditional method of preparing potato juice is to cut a medium- sized potato into thin slices, without peeling the skin, and place the slices overnight in a large glass filled with cold water. The water should be drunk in the morning on an empty stomach. Fresh juice can also be extracted from potatoes. A medium- sized potato should be diluted with a cup of water and drunk first thing in the morning. Arthritis Treatment Using Other Raw Juices. One cup of green juice, extracted from any green leafy vegetable, mixed in equal proportions with carrot, celery, and red beet juices is good for arthritis. The alkaline action of raw juices dissolves the accumulation of deposits around the joints and in other tissues. A cup of fresh pineapple juice is also valuable, as the enzyme bromelain in fresh pineapple juice reduces swelling and inflammation in osteoarthritis and rheumatoid arthritis. Arthritis Treatment Using Sesame Seeds. A teaspoon of black sesame seeds, soaked in a quarter cup of water and kept overnight, has been found to be effective in preventing frequent joint pains. The water in which the seeds are soaked should also be taken along with the seeds first thing in the morning. Arthritis Treatment Using Copper. Drinking water kept overnight in a copper container accumulates traces of copper, which is said to strengthen the muscular system. A copper ring or bracelet is worn for the same reason. Arthritis Treatment Using Calcium. Studies have shown that calcium can help arthritis. Several patients have discovered that joint pains have either been relieved or have disappeared entirely after taking calcium. This mineral should be taken in the form of calcium lactate. Two teaspoons of calcium lactate, each teaspoon providing 4. Arthritis Treatment Using Garlic. Garlic is another effective remedy for arthritis. It contains an anti- inflammatory property which accounts for its effectiveness in the treatment of this disease. Garlic may be taken raw or cooked according to individual preference. Arthritis Treatment Using Bananas. Bananas, being a rich source of vitamin B6, have proved useful in the treatment of arthritis. A diet of only bananas for three or four days is advised in treating this condition. The patient may eat eight or nine bananas daily during this period and nothing else. Arthritis Treatment Using Lime. Lime has also been found beneficial as a home remedy for arthritis. The citric acid found in lime is a solvent of uric acid which is the primary cause of some types of arthritis. The juice of one lime, diluted with water, may be taken once a day, preferably first thing in the morning. Arthritis Treatment Using Alfalfa. A tea made from the herb alfalfa, especially from its seeds, has shown beneficial results in the treatment of arthritis. One teaspoon of alfalfa seeds may be added to one cup of water. Three to four cups of this tea should be taken daily by arthritics for at least two weeks. Arthritis Treatment Using Green Gram Soup. Another home remedy found useful in relieving pains in the joints is the use of green gram soup. This soup should be prepared by mixing a tablespoon of green gram in a cup of water, with two crushed garlic cloves. It should be taken twice a day. Arthritis Treatment Using Castor Oil. Treatment with castor oil has been found beneficial in arthritis. The procedure, as prescribed by a Spanish doctor, is to boil two tablespoons of castor oil over a stove burner. The oil should then be poured into a glass of fresh orange juice and taken before breakfast daily till the disease is cured. Take no pills or vitamins that you can do without; they could prevent success. Stop the Parasite Program and Kidney Cleanse, too, the day before. Following a canine liver disease diet is an important treatment tool for dogs with compromised liver function. A dietary change for a dog with canine liver disease. Losing weight without trying may be a sign of stomach cancer. A loss of appetite or not wanting to eat certain foods may develop. WebMD explains the symptoms and treatment of hemochromatosis and alpha-1 antitrypsin deficiency, both inherited conditions. First Signs and Symptoms of Stomach Cancer. Stomach cancer, also called gastric cancer, develops in the tissues lining the stomach. According to the National Cancer Society, approximately 2. There are no known exact causes of stomach cancer. Things that increase the risk of gastric cancer include peptic ulcers caused by H. Early stomach cancer often does not cause symptoms, but symptoms increase as the cancer grows. Having these symptoms does not always indicate cancer. ![]() A feeling of fullness or tightness in the abdomen may be a first sign of gastric cancer. Pressure or occasional sharp pains, excessive burping or a feeling of general discomfort may occur. Heartburn and indigestion is common. Eating may increase the pain or discomfort. People with stomach cancer may have trouble swallowing. As the disease progresses, swallowing becomes even more difficult as the cancer grows. If the cancer is high in the stomach, swallowing troubles occur sooner. Nausea and vomiting indicates many different problems that can range from a virus, food poisoning or an ulcer to something more serious like stomach cancer. If nausea and vomiting do not go away or get increasingly severe, or if there is blood in the vomit, contact the doctor. Losing weight without trying may be a sign of stomach cancer. A loss of appetite or not wanting to eat certain foods may develop over time. A feeling of being full even when still hungry may limit eating leading to weight loss. As the cancer progresses, the stomach or abdomen may feel bloated. Swelling of the abdomen may indicate fluid buildup or tumor growth. It may look larger, or distended, even when no rapid weight gain occurs. Blood present in vomit or bowel movements can be a sign of stomach cancer. Bleeding that starts in the stomach may be seen as bright red blood in vomit, vomit that looks like coffee grounds, bowel movements that are black or tarry or have bright or dark red blood coating the stool. People who normally are very active with lots of energy may feel tired or unable to keep up with their normal activities. Vague, non- specific complaints about not feeling well should be investigated to determine the cause. An overall decline in health can be a sign of many problems, including stomach cancer. Liver Cleanse - Recipe. Extracted from: The Prevention of all Cancers). The idea of cleansing ones colon has been well documented in many civilizations as far back as 5000 years ago. Doctors performed colonics. Kidney Pain: Symptoms and Treatment. The excruciating pain, that you experience in the middle or lower back, is actually kidney pain. Kidney disease, kidney stone and. This is particularly important in any disease- prevention program. Cleansing the liver of gallstones dramatically improves digestion, which is the basis of your whole health. You can expect your allergies to disappear, too, more with each cleanse you do! Incredibly, it also eliminates shoulder, upper arm, and upper back pain. ![]() ![]() Extending from the inferior end of the large intestine’s cecum, the human appendix is a narrow pouch of tissue whose resemblance to a worm inspired its alternate.You have more energy and increased sense of well being. The liver is full of tubes (biliary tubing) that deliver the bile to one large tube (the common bile duct). The gallbladder is attached to the common bile duct and acts as a storage reservoir (see page). Eating fat, protein, or citric acid triggers the gallbladder to squeeze itself empty after about 2. For many persons, including children, the biliary tubing is choked with gallstones. Some develop allergies or hives but some have no symptoms. ![]() When the gallbladder is scanned or x- rayed nothing is seen. Typically, they are not in the gallbladder. Not only that, most are too small and not calcified, a prerequisite for visibility on x- ray. There are over half a dozen varieties of gallstones, most of which have cholesterol crystals in them. They can be black, red, white, green or tan colored. The black ones are full of wheel bearing grease and motor oil, which turns to liquid in a warm place. The green ones get their color from being coated with bile. Other stones are composites—made of many smaller ones—showing that they regrouped in the bile ducts some time after the last cleanse. It is also thought to slow the flow of lymphatic fluid. Imagine the situation if your garden hose had marbles in it. Much less water would flow, which in turn would decrease the ability of the hose to squirt out the marbles. With gallstones, much less cholesterol leaves the body, and cholesterol levels may rise. But it should not be done before the parasite program, and for best results should follow the kidney cleanse. In this way . No stomach infection such as ulcers or intestinal bloating can be cured permanently without removing these gallstones from the liver. Cleanse your liver twice a year. Preparation. You can't clean a liver with living parasites in it. You won't get many stones, and you will feel quite sick. Zap daily the week before, or get through three weeks of parasite- killing before attempting a liver cleanse. If you are on Maintenance Parasite Program, you are always ready to do the cleanse. You want your kidneys, bladder and urinary tract in top working condition so they can efficiently remove any undesirable substances incidentally absorbed from the intestine as the bile is being excreted. Don't skip this or you may have the worst night of your life! Stop the Parasite Program and Kidney Cleanse, too, the day before. Even stop zapping and taking drops. Zappicate the oil to destroy traces of benzene and PCBs or add a few drops of hydrochloric acid to the bottle and shake. This allows the bile to build up and develop pressure in the liver. Higher pressure pushes out more stones. Limit the amount you eat to the minimum you can get by on. You will get more stones. The earlier you stop eating the better your results will be, too. In fact, stopping fat and protein the night before gets even better results. Finish eating by 1. P. M. Do not eat or drink after 2 o'clock. If you break this rule you could feel quite ill later. Mix 4 Tbsp (6. 0 gr). This makes four servings, . Set the jar in the refrigerator to get ice cold (this is for convenience and taste only). PM. Drink one serving (. If you did not prepare this ahead of time, mix 1 Tbsp. You may rinse your mouth, but spit out the water. Repeat by drinking another . Get your bedtime chores done. The timing is critical for success. P. M. Squeeze the grapefruit by hand into the measuring cup. Remove pulp with fork. You should have at least . You may use lemonade. Add this to the olive oil. Also, add Black Walnut Hull Tincture. If you haven’t gotten stones out in the last few cleanses, add citric acid to bring success. Also, using 2/3 (1. Epsom salts instead of . Close the jar tightly and shake hard until watery (only fresh citrus juice does this). Don't be more than 1. You will get fewer stones. P. M. Drink the potion you have mixed. Take 4 ornithine capsules with the first sips to make sure you will sleep through the night. Take eight if you already suffer from insomnia. Drinking through a large plastic straw helps it go down easier. You may use salad dressing, syrup, or straight sweetener to chase it down between sips. Take it to your bedside if you wish. Get it down within five minutes (1. If you had difficulty getting stones out in the past add . You may put it in capsules. Lie down immediately. You might fail to get stones out if you don't. The sooner you lie down the more stones you will get out. Be ready for bed ahead of time. Don't clean up the kitchen. As soon as the drink is down walk to your bed and lie down flat on your back with your head up high on the pillow. Try to think about what is happening in the liver. Try to keep perfectly still for at least 2. You may feel a train of stones traveling along the bile ducts like marbles. There is no pain because the bile duct valves are open (thank you Epsom salts!). Go to sleep, you may fail to get stones out if you don't. Next morning. Upon awakening take your third dose of Epsom salts. If you have indigestion or nausea wait until it is gone before drinking the Epsom salts. You may go back to bed. Don't take this potion before 6: 0. Hours Later. Take your fourth (the last) dose of Epsom salts. You may go back to bed again. After 2 More Hours you may eat. Start with fruit juice. You may add another . Half an hour later eat fruit. One hour later you may eat regular food but keep it light. During the day take the parasite- killing herbs and zap. By supper you should feel recovered. Alternative Schedule 1: Omit the first Epsom salts dose at 6 p. Take only one dose, waiting till 8 p. Change nothing else. Many people still get stones with one less dose. If you do not, do the full course next time. Alternative Schedule 2: Add . Stir till dissolved. Next morning, add . This includes grapefruit. Blend whole apples instead, Red or Golden Delicious. Strain to get . I like to think I have perfected this recipe, but I certainly cannot take credit for its origin. It was invented hundreds, if not thousands, of years ago, THANK YOU, HERBALISTS! How well did you do? Expect diarrhea in the morning. This is desirable. Use a flashlight to look for gallstones in the toilet with the bowel movement. Look for the green kind since this is proof that they are genuine gallstones, not food residue. Only bile from the liver is pea green. The bowel movement sinks but gallstones float because of the cholesterol and automotive grease inside. Count them all roughly, whether tan or green. You will need to total 2. The first cleanse may rid you of them for a few days, but as the stones from the rear travel forward, they give you the same symptoms again. You may repeat cleanses at two- week intervals. Never cleanse when you are ill. They appear as . It may be tan colored, harboring millions of tiny white crystals. Cleansing this chaff is just as important as purging stones. It is very safe. My opinion is based on over 5. None went to the hospital; none even reported pain. However it can make you feel quite ill for one or two days afterwards, although in every one of these cases the Maintenance Parasite Program had been neglected. This is why the instructions direct you to complete the parasite and Kidney Cleanse programs first. Warning: If you do change these recipes in your own way you might expect problems. The liver is quite sensitive to details. It is recommended to seek the help of a therapist. Gallstones are thought to be formed in the gallbladder, not the liver. They are thought to be few, not thousands. They are not thought to be linked to pains other than gallbladder attacks. It is easy to understand why this is thought: by the time you have acute pain attacks, some stones are in the gallbladder, are big enough and sufficiently calcified to see on x- ray, and have caused inflammation there. When the gallbladder is removed the acute attacks are gone, but the bursitis and other pains and digestive problems remain. People who have had their gallbladder surgically removed still get plenty of green, bile- coated stones, and anyone who cares to dissect their stones can see that the concentric circles and crystals of cholesterol match textbook pictures of . Are you ready to advance your running skills so you can increase your distance and strength?! If you want to become a good runner. Jason Fitzgerald and I discuss some of the myths about long-distance running, why runners often neglect strength training, and more. Running Nike and Adidas just rolled out ultra-fast marathon shoes. But do they make sense for the average runner? As part of their rival efforts to break the two-hour. The Healthy Runner’s Diet Follow these six rules for a healthy, whole-foods eating plan designed just for a runner like you. By Liz Applegate, Ph.D. What elite runners eat to get the most out of their training and racing is not a secret. Here is a typical diet and how you can make it fit your training. Want to be a better runner? Here are 5K, 10K, and half-marathon training plans and running tips for beginners to serious runners. The Local Elite ! I’m writing up a “quick” birth story for anyone who is interested in how my 3rd baby entered the world and then hope to get right into blogging again about coming back and how my running is going. The birth was similar in some ways (vaginal, no epidural, extremely painful delivery!) but also different (middle of the night, exhausted, starving momma this time around). I’m going to start by going off on a little tangent and say BRAVO to all moms for carrying and delivering babies regardless of how the process goes. I think one of the worst parts of pregnancy for me is realizing around 8. I made it easier on myself with my 2nd and 3rd child by saying “this is what I want to happen in an ideal world, but I’m ok with anything that has to happen to result in a healthy baby and mom in the end.” Before having my first child, a daughter, I wanted a perfectly magical, natural labor. After taking birthing classes I felt like I knew exactly what labor would be like and I WAS GOING TO DO IT SO WELL! Then I ended up having a long, painful labor that ended with an epidural and I quickly realized I knew absolutely nothing and every labor is different and you really can’t prepare much for what it will really be like other than mentally preparing for ANYTHING. Epidurals happen, c- sections happen, blood transfusions happen, newborns in the NICU happen, the list goes on and on – you are NOT LESS of a woman or mother or person for the way you choose to have your baby or how your body chooses to respond to labor. We are all SUPERWOMEN!! Husband and wife Ryan and Sara Hall are two of America’s premier distance runners. Both were California high school superstars and All-Americans at Stanford. ![]() Moving along. When I would go to bed at night, I would feel almost like I peed my pants a little, but I knew it wasn’t pee. I told my mom who urged me to go to the midwives on Monday. I had an appointment on Thursday and decided to wait until then. Thursday rolled around and I brought my hospital bag to my appointment. ![]() I see the midwives at the hospital where I deliver and I just knew I wouldn’t be going home. I was right. They confirmed I had a leak and I would have to be induced Thursday evening. Posing in front of the hospital after finding out I was going to be induced. I was a little disappointed to be induced. I felt like I did something wrong. But then I remembered what I typed earlier – we are all awesome and having a leak and being induced is not my fault and I’m not “failing” at anything. I did request the midwives check to see if there was a low bag of water that needed to be broken since I felt the leak was high and the baby was still surrounded by plenty of “water” and labor wasn’t going to progress quickly like that. I wasn’t feeling like I was in labor at all. I thought if they would check that and break my water my labor would start to progress. But they recommended not checking due to risk of infection and they would start me on Pitocin. NytroWhey Ultra Elite by ProSource, is a Premium Whey Protein Powder using CFM Whey Isolate from Glambia along with Aminogen. I agreed on the Pitocin and reminded them in a *perfect world* I wanted a natural, vaginal delivery but to offer me an epidural when things got rough and let me make a decision then. My family met me at the hospital but the kids left with our good friends after an hour had passed and it was clearly going to be a longer process than originally expected. I had lunch at noon that day before my 1pm appointment and when I was waiting for a room to clear (2: 3. I wanted to get a snack before they induced me. I assumed I would have a room soon and the induction would be quick, having me eating dinner by 6pm so I said I was fine. I didn’t want to feel full during my labor. Well, that was a horrible idea because I was STILL waiting for a room at 6pm and got started on Pitocin at 7pm. To make a long story short the Pitocin did nothing and I was still waiting for noticeable contractions at 1. I was on a clear liquids diet so kept requesting italian ice and gingerale to give me energy. In my gown and ready to get this show on the road! Face swapping with my husband to pass the time! I was exhausted, starving, and worried the process might take all night and I didn’t feel like my body or mind would be able to handle it. I asked if I was still on a low dose of Pitocin because I was literally feeling nothing but Braxton Hicks feeling contractions. No pain at all. They had been increasing the dose every half hour and said I was up to a high level (still half of what is “allowed” but most people don’t go past the dose I was being given and nothing was happening). The midwife ended up coming in and I asked her to please please PLEASE!!! She agreed and my instincts were correct. Baby was still hanging in tons of water so she broke the water right then, at exactly midnight. Within minutes, the real contractions hit pretty hard. It was now officially Friday morning and I knew my baby would be born sometime on 3/2. I decided if all went well and was normal, I was going to approach this labor like a race – most specifically a marathon. There was going to be the part that was comfortable, then it would be annoyingly uncomfortable, then there would be pain, then it would get unbearable and I would want to throw in the towel, but if I could pass that point (which is the “transition phase” of labor I would “see the finish line” (pushing) and be able to make it through. Luckily, that scenario is exactly how labor went. ![]() When things got really bad, the midwife offered the epidural and I said, “I feel like this is going to be less than 3 hours and I know I can deal with 3 hours of pain so let’s go without it.” I hit many points where I thought I would throw up, then I was sure I would pass out. Strange things crossed my mind like, “will I die?” or “will my baby die” and then “what will happen to my baby?” Most of this time I was laboring alone as the midwives are very much into letting you labor as you wish and not interfering. This is one of the reasons I chose the midwives. ![]() ![]()
![]() My husband was pretending to sleep on the couch, knowing I am independent and like doing hard things on my own! When labor started to seem unbearable I reminded myself the finish line was approaching. I had the advantage of knowing exactly what the “transition phase” felt like from my previous 2 children and knew I was there. When I was ready to push, I buzzed for the midwife and nurses and they came to my room fairly quickly. My husband then got up and joined me and it was go time. I was so tired I started to worry I wouldn’t be able to push the baby out, but on the second contraction after the urge to push, I was holding baby Ryles in my arms. I had 2 hours and 4. I had my reward! Relieved to have my baby in my arms and have the pain stop. So many thoughts and emotions running through my head at this point, but was mostly just relieved. People say you forget the pain of labor, and that happened after my first child (labored for 3. I also forgot the pain almost immediately after my second (he was quick and came just before lunch when I had high energy levels and high spirits and I didn’t have time to get an epidural as I was 1. I arrived at the hospital). But the thing is, I can still imagine and feel the pain of this 3rd baby, even though the pain subsided moments after giving birth. So, don’t believe everything you hear about childbirth and never believe every labor will be the same! Later that morning after I had about 3. I recovered really quickly and was walking around, using the restroom unassisted and doing all the things I needed to do in the first hour or so. Yes, I got LUCKY! I was able to leave the hospital the next day to join my other kids and parents at home and start to learn what it feels like to be a family of 5! Bigham, part of 5! Thank you so much for all of the love and encouragement and I will blog soon about my return to base building, then real training, and finally back to competitive running! Spoiler alert: I’m “participating” in a race 5 weeks postpartum. Unbreakable Runner: Cross. Fit Endurance for Running. In a recent article posted on Active by my former colleague, star author and longtime friend, Matt Fitzgerald, Matt takes up the issue of injury prevention for runners, using an initial mention of Unbreakable Runner to make his point. He writes, “In their book, Mac. Kenzie and Murphy take it as a given that runners who run more get injured more. However, recent research suggests the opposite is true.”The first study Fitzgerald cites was a web survey of 6. Sixty- eight of the respondents reported an injury that hindered their training for at least two weeks. From the data, researchers concluded that runners should put in no less than 1. Fitzgerald also refers to a 2. Researchers focused on overall mileage, speed and frequency of runs. From the data collected, they predicted that injury risk in regards to training load is affected by body- mass index and previous injuries. Fitzgerald then effectively dismisses a program like Cross. Fit Endurance—the subject of Unbreakable Runner—with his own deduction: “Why do runners who run more get injured less?” Fitzgerald posits. He answers that “running alone develops the specific kind of durability that makes the body resistant to running- related injuries.”He adds his bottom- line: “All of the strength training and technique drills in the world won’t match the toughening effect of actual running.”To support this contention, he cites a 2. Both groups would follow a 9- week training program, but the test group first prepared with a four- week phase of pre- conditioning comprised of walking and hopping exercises. Researchers concluded that the four weeks of hopping and walking didn’t have a valuable effect on shielding newbie runners from injury. Only running itself builds the kind of durability that prevents running- related injuries. Drills and strength training just don’t cut it.”I think this is an important discussion to have and I think Matt brings up some valuable insight, especially for beginning runners. From the data, Matt extrapolates that “drills and strength training” just don’t cut it. I assume he’s talking about the inclusion of running drills, bodyweight gymnastic work, mobility and functional- strength training workouts in Mac. Kenzie’s approach, and not the . At any rate, one thing I wish to clarify is the primary messages we wanted to get across in Unbreakable Runner: Unleash the Power of Strength and Conditioning for a Lifetime of Running Strong. I want to underscore the “Lifetime” part of the subtitle a little later on, but first, a stress within Unbreakable Runner I wanted to make is not that it’s the best program or the only program worth following—something Mac. Kenzie seems to be routinely accused of saying. There are so many different types of runners with different goals and different issues, I think a variety of options and ideas is a good thing. Lydiard isn’t for everyone and CFE isn’t for everyone as is Galloway isn’t for everyone or Vigil isn’t for everyone (pity the recreational runner who tries to follow Joe Vigil’s 1. K program, preferably performed at 8. And that’s a core message in the book: We wanted to communicate an accurate picture of Cross. Fit Endurance and offer it to those who might be frustrated with injuries from the programs they’ve been following, or for those who might find the variety and all- around athleticism appealing. But we weren’t out to force it down anyone’s throat. Recently, a link to a story on the book was announced with the Twitter text: . He doesn’t dispute that high- mileage programs can work—in fact, the foreward is written by the human odometer, Dean Karnazes—what Brian does suggest is that a runner should look for every opportunity to minimize the wear and tear of running and factors, like a poor diet or not getting enough sleep, that lead to chronic inflammation, which science clearly links to premature aging. As an example, if you ask Mac. Kenzie what the number one benefit of a Cross. Fit workout is for a runner, he’s going to talk about how functional movements, performed under load and at high- intensity, can do wonders for a coach trying to sort out biomechanical weaknesses, imbalances and other “holes” that ultimately, down the road, will probably be the cause of an injury. The weaknesses are exposed well before they manifest themselves in a tweak. There’s also the value of the strength work. As Jay Dicharry, MPT, puts forth in his detailed examination of biomechanics and running, the excellent book, Anatomy for Runners, nothing drives him crazier in his practice then when a veteran runner comes into his office with a chronic injury (or injuries) and Dicharry asks what the runner has been doing as far as routine maintenance over the years, and and the answer is . To illustrate his point, Dicharry uses the metaphor of a car mechanic talking to a customer whose car is breaking down at 7. Dicharry also advocates the style of strength training that Mac. Kenzie does: Weight training (at high intensity) requires the runner to produce forces well above those seen during running. It’s possible to activate a very high percentage of a runner’s muscle mass, with minimal physiologic fatigue. The study I would be interested in seeing would be a six week (or more) preparation program that went above and beyond walking and hopping and prepared new runners with movement drills and basic functional strength training moves. Then compare them to a control group and a nine- week training program. But even then, that’s just going to offer another ray of information for the discussion. The one study that I know of that looked at a pool of very good runners over a long time has been conducted by Jack Daniels, Ph. D., the longtime coach, researcher and author of The Daniels Running Formula. In a phone interview about a year and a half ago, Daniels described to me how he’s kept tabs on the elite runners he first studied circa 1. During the call, he told me how he had completed a third survey with his cohort, and said there was one conclusion he could draw in regards to those who still were enjoying their running and running well. The ones who had run the least were the least broken, in other words. That’s just another piece of the puzzle, of course, when it comes to the discussion of running mileage. Steve Magness, author of The Science of Running, examines the subject of volume in his book and concludes that we just don’t know enough—it’s his contention that there just aren’t enough studies on the subject that one can use research alone to make a decision on what mileage level is the best mileage level. One of my favorite people to talk to on the subject is Dr. Brian Hickey, a Ph. D at Florida A& M. In his 4. 0s, Hickey has been a running and track geek since he was a kid, and he’s applied his vast knowledge of exercise science toward his own athletic career. Even though he’s been competing since high school and ran at Syracuse, he still loves to spend his summers finding duathlons and Masters track meets to frequent. I seem to recall him telling me that he not only likes to enter just myriad race distances, from the 4. That the guy has been at it for more than two decades and is still racing a lot is one thing; it’s another thing to be able to do a field event that I can barely watch because of the impact stress involved. Hickey, in fact, was a like a third author on the book, Unbreakable Runner, and I’m looking forward to reporting more about what he has to say. He’s all about minimum effective dose when it comes to running miles, using functional strength movements and heavy weights as part of his long- term durability plan. If you’re in your 2. CFE- like workouts to supplant the easy maintenance runs? I think the answer is very individual, and may have something to do with the quality of your mechanics and any mobility issues you have. A thought sparked in discussions with Hickey is that the day that you end up in your 4. Or is it the inevitable result of all those steps you took doing 6. It’s different if you’re a professional runner who is out to make a killing and be finished with running by the age of 2. But it’s a different thing for the age- grouper sort who wants to run forever. I totally agree with Fitzgerald that running produces adaptations that lead to stronger connective tissue, bone density and the like—durability, as he puts it. My question—for those who love running and want to be able to run in their later years—is what else can you do besides just more running? What can you do to insure your bet? That’s what Unbreakable Runner is about. In their new book, Unbreakable Runner, Cross. Fit Endurance. Murphy examine long- held beliefs about how to train, tearing down those traditions to reveal new principles for a lifetime of healthy, powerful running. Unbreakable Runner includes Cross. Fit- based training programs for the most popular running race distances from 5. K to ultramarathon. Now available! Autographed copies of Unbreakable Runner from Brian Mac. 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